研究目的
Investigating the size effect of metal nanodome arrays on the performance characteristics of a plasmonic biosensor using reflection spectroscopy.
研究成果
The study concludes that dome diameter significantly affects the optical properties and sensing performance of metal nanodome arrays, with larger diameters improving bulk RI sensitivity and smaller diameters enhancing sensor signals against DNA-AuNPs immobilization. The effect of metal thickness was moderate, indicating that dome diameter is a more critical parameter in designing plasmonic biosensors.
研究不足
The study focuses on the size effect of metal nanodome arrays on plasmonic biosensor performance, with limitations including the specific range of dome diameters (100 to 500 nm) and metal thicknesses (10 to 100 nm) investigated. The effect of metal thickness was found to be moderate, suggesting potential areas for optimization in sensor design.
1：Experimental Design and Method Selection:
The study involves the creation of Ag and Au nanodome arrays through a bottom-up nanofabrication process, controlling dome diameter and metal thickness. Reflectivity measurements are conducted to observe changes in resonance dip wavelengths and widths.
2：Sample Selection and Data Sources:
Polystyrene beads solutions of various diameters are used to create the nanodome arrays. Reflectivity spectra are measured in contact with air and water.
3：List of Experimental Equipment and Materials:
Includes polystyrene beads, gold(III) chloride hydrate, dopamine hydrochloride, ethylene glycol, TritonX, phosphate buffered saline tablets, and single-stranded DNA sequences.
4：Experimental Procedures and Operational Workflow:
The fabrication involves spin coating PS beads onto glass substrates, depositing Ag or Au films by Rf sputtering, and annealing. Optical measurements are performed using a laboratory-build optical setup.
5：Data Analysis Methods:
Reflectivity spectra are analyzed to determine resonance wavelengths and shifts, with bulk RI sensitivity calculated from shifts in resonance wavelength against refractive index changes.
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