研究目的
To review the progress made in developing MALDI-TOF MS applications beyond conventional identification of bacteria and yeast for infectious diseases diagnostics.
研究成果
MALDI-TOF MS has significantly advanced the field of infectious diseases diagnostics, offering rapid, cost-effective, and accurate identification of pathogens. The technology's utility extends beyond organism identification to include antimicrobial susceptibility testing and direct identification from clinical specimens, promising to further improve patient care.
研究不足
The review highlights the need for standardization of extraction methods for mycobacteria and fungi, the challenges in identifying polymicrobial infections directly from blood cultures, and the variability in performance across different MALDI-TOF MS systems and databases.
