研究目的
Design and fabrication of a smart liquid quantum dots (LQDs) with high biomolecules selectivity and specificity for Tyrosine (Tyr) detection.
研究成果
The Tyr-responsive CdSe-LQDs system exhibits excellent selective fluorescence/macroscopic response for Tyr and reversible fluidic features, highlighting its potential as a platform for biological molecules recognition and separation in the future.
研究不足
The research is still in its infancy regarding the design of smart LQDs in response to external stimuli for biosensor applications. The study focuses on Tyr detection, and the applicability to other biomolecules needs further exploration.
1：Experimental Design and Method Selection:
The synthesis of PEGylated calix[4]arene derivatives (PCAD) and its application to fabricate a Tyr-responsive CdSe-LQDs system through host-guest chemistry.
2：Sample Selection and Data Sources:
The use of 11 different types of amino acids including Trp, Ser, Tyr, Pro, Arg, Lys, Leu, Thr, Phe, Cys and His for testing the selectivity of CdSe-LQDs.
3：List of Experimental Equipment and Materials:
Transmission electron microscope (TEM), Infrared spectra (IR), Applied NanoFluorescence Spectrometer, OCA 20 contact angle system, Differential Scanning Calorimetry (DSC).
4：Experimental Procedures and Operational Workflow:
Preparation of PCAD modified CdSe-LQDs, fluorescence spectrum recording, contact angle measurement, DSC and heat-cool cycle experiments.
5：Data Analysis Methods:
Analysis of fluorescence quenching, contact angle changes, and DSC results to evaluate the selectivity and responsiveness of CdSe-LQDs towards Tyr.
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