摘要： Background: Both pulsed dye laser(PDL) and Fractional CO2 laser(FCO2L) are used commonly for the treatment of hypertrophic scars. Objective: to compare the efficacy of PDL and FCO2L on hypertrophic scars. Patients and Method: One part of each scar, or one of the two similar scars in 35 patients were treated with PDL and the other parts, or scars were treated with FCO2L. The parameters used for FCO2L were: Power=30 watts, Pulse energy=50 mJoules, Density = 200spots/cm2. The parameters used for 585 nm PDL were 9 joules/cm2 with 5mm spot size. The FCO2L side were treated for 3 passes to debulk the scar. The coagulated tissue was wiped out before the next pass. The PDL side were treated with 2 superimposed passes. The procedures repeated every month for 4 months. Results: after 4 sessions of laser therapy, both sides showed remarkable improvement but no meaningful difference detected between 2 areas that were treated with PDL and fractional CO2 lasers (p?0.05). The mean Vancouver scar scale was 7.31±1.93 In the beginning and 4.26±1.48 for FCO2L and 4.33±1.70 for PDL one months after the final session. Conclusion: both PDL and Fractional CO2 lasers were equally effective on hypertrophic scars.