研究目的
Investigating the therapeutic effects of chitosan-coated graphitic carbon nanocages (CS-GCNCs) loaded with 5-fluorouracil (5Fu) for cancer therapy when activated by 808-nm laser and microwave co-irradiation.
研究成果
The study demonstrates that CS-GCNCs(5Fu) exhibit low cytotoxicity, sustained drug release, and high efficiency in cancer therapy under 808-nm laser and microwave co-irradiation. The combination of chemotherapy and enhanced photothermal therapy offers a promising approach for cancer treatment.
研究不足
The study primarily focuses on the in vitro and in vivo effects of CS-GCNCs under specific conditions. The clinical applicability and long-term effects of the treatment require further investigation.
1：Experimental Design and Method Selection:
The study involved the synthesis of CS-GCNCs and their characterization using various techniques. The cytotoxicity, drug release, and therapeutic efficiency under laser and microwave co-irradiation were evaluated.
2：Sample Selection and Data Sources:
Human nasopharyngeal carcinoma (CNE) cell line and BALB/c nude mice were used for in vitro and in vivo studies, respectively.
3：List of Experimental Equipment and Materials:
Equipment included a microwave therapy instrument, thermal imager, flow cytometer, and others. Materials included GCNCs, chitosan, 5-fluorouracil, and various reagents.
4：Experimental Procedures and Operational Workflow:
The study involved the preparation of CS-GCNCs, evaluation of their properties, cytotoxicity assays, drug release studies, and in vivo tumor inhibition experiments under various irradiation conditions.
5：Data Analysis Methods:
Statistical analysis was performed using non-parametric tests and Student t-test to compare the results.
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