摘要： Normal wound healing is a well-orchestrated process that occurs in 3 characteristic overlapping phases after injury: in?ammation, proliferation, and remodeling/maturation. During the proliferation phase of healing, granulation tissue grows from the base of the wound, ?lling the volume de?cit of the wound, and facilitating epithelialization and wound closure. Aberrantly prolonged stimulation of ?broplasia and angiogenesis, believed to be caused by an imbalance of matrix metalloproteinases, results in hyper-granulation, or “proud ?esh.” Risk factors contributing to the development of hypergranulation include wounds that heal by secondary intention, a prolonged (>1 week) in?ammatory phase of healing, or exposure to excessive external friction or moisture. Hypergranulation is clinically identi?able as red, friable, exophytic tissue that spills over the edges of the wound. Its presence impedes normal wound healing, resulting in persistent wounds that diminish quality of life (pain, bleeding, or malodor), contributing to development of contractures in burn wounds and grafts, and increasing risk of subsequent infection. Treatment is often dif?cult, and multiple modalities have been reported in the literature with varying success including chemical cautery with silver nitrate or tricholoracetic acid, both intralesional or topical corticosteroids, hydrocolloid dressings, surgical excision, pulsed dye laser (PDL), and potassium titanyl phosphate (KTP) laser.1,2 Treatment of surgical, traumatic, and burn scars with the ablative fractional CO2 laser is a recent, highly successful development.3 This infrared laser targets water and vaporizes vertical microcolumns of tissue, creating a zone of coagulation surrounding the ablated microcolumns. After this controlled microscopic injury, a sequential and predictable induction of growth factors and cytokines occurs, leading to a coordinated expression of matrix metalloproteinases, growth factors, and heat-shock proteins.4 Three recently reported case series detail the successful treatment of 10 patients with chronic ulcers with ablative fractional laser resurfacing.3–5 In this report, we describe the successful treatment of 2 patients with hypergranulation tissue using ablative fractional laser resurfacing. To the best of our knowledge, this has not previously been described in the literature.