研究目的
Investigating the use of Red Blood Cells as optical lenses for direct writing of laser-induced refractive index changes on Lithium Niobate crystal surfaces.
研究成果
The study demonstrates the possibility to imprint phase information of RBCs into x-cut Fe:LN crystal, showing that discocytes and spherical-like RBCs imprint diverse phase discontinuities due to their diverse focusing abilities. This establishes a printing technique to fix into a solid material the optical fingerprint of living samples, with potential applications in diagnostics and cell patterning.
研究不足
The exposure time must be carefully calibrated to avoid altering the RI across the whole illuminated area, not just in correspondence of the cells. The PR effect in x-cut LN produces non-isotropic imprints.
1：Experimental Design and Method Selection:
The study employs a digital holographic microscope to set bio-PL writing and quantitatively measure phase inhomogeneity. The setup allows switching between writing-on and writing-off modes by rotating the linear laser light polarization.
2：Sample Selection and Data Sources:
A single layer of RBCs is placed on the surface of a x-cut iron doped LiNbO3 crystal.
3：List of Experimental Equipment and Materials:
The setup includes a collimated laser beam (λ = 473 nm), microscope objectives, half wave plates, mirrors, linear polarizers, beam splitters, and a petri dish.
4：Experimental Procedures and Operational Workflow:
RBCs are illuminated in writing-on mode to focus incoming light and locally modify the refractive index. The process is monitored and recorded via digital holography.
5：Data Analysis Methods:
Quantitative Phase Maps (QPMs) are retrieved from holograms to analyze the phase shift introduced by RBCs and local inhomogeneity induced into the LN.
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