研究目的
To demonstrate three-dimensional intravascular flow imaging compatible with routine clinical image acquisition workflow by means of megahertz (MHz) intravascular Doppler Optical Coherence Tomography (OCT).
研究成果
The study successfully demonstrated MHz intravascular Doppler OCT, enabling direct measurement of velocity projections along the OCT beam within a range of 37.5 cm/s without phase wrapping. It achieved simultaneous morphological and Doppler flow pattern imaging at high speeds, offering new opportunities for coronary flow studies and diagnosis.
研究不足
The insertion of the catheter can affect the flow pattern inside the coronary artery due to the reduction in free lumen cross-sectional area. Additionally, the strong attenuation of the OCT signal in blood necessitates the use of imaging contrasts like intralipid, which may have clinical safety considerations.
1：Experimental Design and Method Selection:
The study utilized a 1.5 MHz Fourier Domain Mode Locked (FDML) laser and a 1.1 mm diameter motorized imaging catheter for OCT imaging. A post-processing method was developed to compensate for the drift of the FDML laser output, enabling the resolution of Doppler phase shifts between adjoining OCT A-line datasets.
2：5 MHz Fourier Domain Mode Locked (FDML) laser and a 1 mm diameter motorized imaging catheter for OCT imaging. A post-processing method was developed to compensate for the drift of the FDML laser output, enabling the resolution of Doppler phase shifts between adjoining OCT A-line datasets.
Sample Selection and Data Sources:
2. Sample Selection and Data Sources: Imaging experiments were conducted in phantoms, micro channels, and swine coronary arteries in vitro.
3：List of Experimental Equipment and Materials:
The OCT system included a 1.5 MHz FDML laser, a motorized imaging catheter, and a data acquisition system. The system was operated at 600 frames/s.
4：5 MHz FDML laser, a motorized imaging catheter, and a data acquisition system. The system was operated at 600 frames/s.
Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: The system was used to acquire volumetric datasets at high speeds, with a pullback speed of 40 mm/s. Doppler phase shifts were measured and interpreted to estimate flow direction and velocity.
5：Data Analysis Methods:
A post-processing method was applied to compensate for laser drift and to analyze Doppler phase shifts for flow velocity and direction estimation.
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