摘要： Background: For ethnic skin, laser surgery for pigmented lesions presents a special challenge due to the increased risk of postprocedural complications—erythema, blistering, and postinflammatory dyspigmentation. Aims: To describe the treatment of ephelides in Asian skin treated with a picosecond 785-nm laser. Patients/Methods: The first patient with ephelides on the cheeks and nose was treated with a picosecond 785-nm laser with the treatment parameter of 1.2 J/cm2 and 3-mm spot size. The second patient with ephelides on the cheeks was treated with a picosecond 785-nm laser with the treatment parameter of 1.3 J/cm2 and 3-mm spot size. Results: After a single laser session, both patients achieved appreciable improvement without any complications. Conclusion: This is the first case series demonstrating the efficacy and safety of the picosecond 785-nm laser for the treatment of ephelides in Asian skin.