摘要： So far, cadmium-containing quantum dots (QDs), such as cadmium telluride (CdTe), have been known for causing time- and dose-dependent toxicity for cells, tissues or organs in living organisms. Yet, there has been no a unified conclusion whether indium phosphide (InP) QDs, a kind of non-cadmium QDs, have the same effects on these structures, especially on female germ cells. In this work, we evaluated the adverse effects of InP/ZnS based core/shell QDs on oocytes of the Kunming mice. The immature oocytes were co-cultured with InP/ZnS QDs at concentrations of 0, 0.2 μg/mL, 2 μg/mL, and 20 μg/mL for 16 hours, respectively. The statistics of morphology showed that InP/ZnS QDs significantly (P<0.05) affected the maturation rate of oocytes at concentrations above 2 μg/mL, while measurements of diameter didn’t seem to display difference between the groups. Fluorescence images showed that the uptakes of QDs by granulosa cells increased with the increasing concentration, but no fluorescence signal of QDs was detected inside the oocytes. The abnormality rate of both spindles and chromosomes in control group was the same as that in experimental groups. However, two hormone levels were both disturbed by InP/ZnS QDs. These results indicated that InP/ZnS QDs decreased the oocytes maturation in a dose-dependent manner by changing the culture environment, which was similar to the effects of cadmium-containing QDs. This study provides the reproductive toxicology data of InP/ZnS QDs, which is useful for biomedical safe application of QDs in future.