研究目的
To propose an in-vivo and online temperature monitoring scheme by using FBG arrays during tumor treatment with nanosecond pulse electric field and to understand the interaction between nsPEF and tissue.
研究成果
The FBG sensing system effectively monitored temperature changes during nsPEF treatment, showing that the temperature rise does not exceed 6℃ for 300 pulses. This scheme provides a valuable means for nsPEF-tissue interaction research, demonstrating that nsPEF does not significantly heat the tissue, thus excluding a hyperthermic effect.
研究不足
The study is limited to the specific conditions of nsPEF treatment and may not be directly applicable to other treatment modalities. The use of FBGs, while advantageous, may have limitations in terms of spatial resolution and the need for calibration.
1：Experimental Design and Method Selection:
A fiber Bragg grating (FBG) sensing system was used to monitor the temperature at the surface of/inside the liver tissue of a rabbit under nsPEF. Single point and multi-point measurements were carried out.
2：Sample Selection and Data Sources:
A rabbit with liver tumor was anesthetized and fixed to the board for the experiment.
3：List of Experimental Equipment and Materials:
FBGs re-coated with curable polymer material, electrodes, and a demodulator (MOI SM125) were used.
4：Experimental Procedures and Operational Workflow:
FBGs were inserted into the tumor around electrodes to monitor temperature change during therapy. The reflection signal was recorded and analyzed.
5：Data Analysis Methods:
The evolution of temperature changes was monitored and analyzed, and theoretical modeling was performed using the bio-heat transfer equation.
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