研究目的
Investigating the feasibility of a cone-shaped fiber probe for superficial photothermal laser ablation (SPLA) of mucosal lesions in an ex-vivo sheep esophageal model.
研究成果
The cone-shaped fiber probe using 1505-nm infrared laser radiation is capable of providing both superficial and highly effective photothermal mucosa ablation of the sheep esophagus, ex vivo. This probe approach, with further development, may hold promise for endoscopic therapy of targeted-lining areas during a single-session procedure and could be extended to other endoscopy therapy applications.
研究不足
1. The Arrhenius integral does not account for the nonlinear response of tissue to laser-induced thermal effects. 2. Accurate beam diameter analysis is required to determine the beam diameter and focal length produced by the fiber probe. 3. The chemically etched fiber tip is fragile and produces a narrow ablation area, necessitating investigation into more suitable designs. 4. The depth of therapy does not necessarily correlate to an anatomical landmark, and treatment time may limit control of therapy depth due to residual thermal effects. 5. More rigorous histological analysis combined with an in vivo animal model is required for optimal therapeutic window determination.
