研究目的
To synthesize and characterize selenium-decorated graphene quantum dots (GQDs) for application in photodynamic therapy (PDT), focusing on enhancing photoluminescence (PL) efficiency and singlet oxygen generation.
研究成果
Selenium-decorated GQDs showed enhanced PL efficiency and singlet oxygen generation, making them promising for PDT applications, including deep tumour treatment. The study demonstrated the potential of GQDs in PDT with minimal side effects and directional delivery capabilities.
研究不足
The study focused on the synthesis and characterization of selenium-decorated GQDs for PDT, but did not explore in vivo applications or the long-term stability of the GQDs in biological environments.
1：Experimental Design and Method Selection:
GQDs were synthesized through pyrolysis of citric acid, decorated with selenium at different molar ratios, and surface-modified with polyethylene glycol (PEG) for conjugation with protoporphyrin IX (PpIX).
2：Sample Selection and Data Sources:
The study used citric acid for GQDs synthesis, sodium selenite for selenium decoration, and PpIX for conjugation.
3：List of Experimental Equipment and Materials:
Equipment included X-ray diffraction (XRD) (X'Pert Pro model, Philips Company), transmission electron microscopy (TEM) (EM 208S model), and a stirrer. Materials included citric acid, sodium selenite, PEG 6000, and PpIX.
4：Experimental Procedures and Operational Workflow:
GQDs were synthesized, decorated with selenium, modified with PEG, and conjugated with PpIX. Singlet oxygen generation was measured using anthracene as an indicator under UVC light.
5：Data Analysis Methods:
PL intensity and singlet oxygen generation were analyzed to evaluate the efficiency of the synthesized GQDs in PDT.
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