研究目的
To review the latest advances in plasmonic sensor platforms for label-free biomolecule detection and highlight diagnostic applications targeting immune cytokine biomarkers, focusing on novel plasmonic nanostructures and their integration with microfluidic systems for real-time, highly sensitive, label-free cytokine detection.
研究成果
Integrated nanoplasmonic microfluidic biosensors could overcome some of the major challenges faced in conventional diagnosis techniques and have immense potential as transformative analytical platforms for accurate and comprehensive analysis of the immune system.
研究不足
Challenges include simultaneously achieving high sensitivity, selectivity, multiplexity, and spatial-temporal resolution, which are consequential to the accuracy, rapidness, and reproducibility of on-chip cellular secretory analysis, especially at the single-cell level. Additionally, the design, selection, and optimization of cell isolation mechanisms in microfluidic systems that are optical compatible with label-free nanoplasmonic sensing remain critical issues.
