1：Experimental Design and Method Selection:

The study involved the synthesis of a molecularly imprinted polymeric nanofilm on a gold plasmonic nanosensor surface for cocaine detection. The methodology included the use of acrylamide as a functional monomer and cocaine as the template molecule, with ethylene glycol dimethacrylate as the cross-linker and α,α’-azobisisobutyronitrile as the initiator.

2：Sample Selection and Data Sources:

Cocaine solutions were prepared in a broad concentration range between

3：2-100 μg/mL in an acetonitrile-phosphate buffer mixture for kinetic studies. List of Experimental Equipment and Materials:

Instruments used included an SPRimager II system for kinetic studies, atomic force microscopy (AFM) for surface morphology characterization, an auto-nulling imaging ellipsometer for thickness measurements, and contact angle measurements for hydrophilicity assessment.

4：Experimental Procedures and Operational Workflow:

The gold surface was cleaned and modified with allyl mercaptan, followed by the polymerization of the molecularly imprinted polymeric nanofilm. Kinetic studies were performed by applying cocaine solutions to the SPRimager II system at 24oC.

5：Data Analysis Methods:

The refractive index changes (ΔR) were observed in real-time, and the data were analyzed using Digital Optics V++ and Microsoft Excel software.