研究目的
Investigating the synthetic potential and specific features of the reaction of benzimidazole with bis(iodomethyl)tetramethyldisiloxane at different temperatures.
研究成果
The reaction of benzimidazole with bis(iodomethyl)tetramethyldisiloxane at 160°C leads to the formation of linear N-alkylation products, while at 190°C, both cyclic and linear siloxane structures containing a benzimidazole fragment are formed. The study demonstrates the utility of NALDI-TOF MS in analyzing such reactions without a matrix.
研究不足
The study focuses on the reaction at two specific temperatures (160 and 190°C), and the analysis is limited to the products detectable by NALDI-TOF MS.
1：Experimental Design and Method Selection:
The reaction of benzimidazole with bis(iodomethyl)tetramethyldisiloxane was studied at different temperatures (160 and 190°C) using matrix-free laser desorption/ionization time-of-flight mass spectrometry (NALDI-TOF MS).
2：Sample Selection and Data Sources:
The reaction mixtures obtained at 160 and 190°C were analyzed.
3：List of Experimental Equipment and Materials:
A Bruker Daltonics UltrafleXtreme III TOF/TOF mass spectrometer equipped with a nitrogen laser was used.
4：Experimental Procedures and Operational Workflow:
The reaction mixtures were dissolved in acetonitrile, applied to an NALDITM target, and air-dried before analysis.
5：Data Analysis Methods:
The MS/MS spectra were analyzed to determine the structures of the products based on their fragmentation patterns.
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