研究目的
Investigating the use of porphyrins as photoredox catalysts in the arylation of enol-acetates to yield α-arylated aldehyde and ketone building blocks, comparing batch and continuous flow approaches.
研究成果
The study demonstrates that porphyrins, especially meso-tetra(pentafluorophenyl)porphyrin, are effective SET photocatalysts for the arylation of enol-acetates. The continuous flow approach offers advantages in terms of safety, scalability, and efficiency over batch conditions.
研究不足
The study is limited to the use of specific porphyrins and substrates, and the scalability of the continuous flow approach needs further optimization for industrial applications.
1：Experimental Design and Method Selection:
The study involved the use of porphyrins as SET photocatalysts in photoarylations of enol-acetates with diazonium salts under both batch and continuous flow conditions.
2：Sample Selection and Data Sources:
Different porphyrins were tested as photocatalysts, and various enol-acetates and diazonium salts were used as substrates.
3：List of Experimental Equipment and Materials:
Homemade batch reactor with LEDs, continuous flow setup with PFA tubing, and standard laboratory equipment for synthesis and analysis.
4：Experimental Procedures and Operational Workflow:
Reactions were conducted under visible light irradiation, with variations in temperature, solvent mixtures, and photocatalyst loading to optimize yields.
5：Data Analysis Methods:
Products were analyzed by NMR, GC-MS, and isolated yields were determined.
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