研究目的
To develop a one-pot assembly approach for precise control of core?satellite nanocluster architectures in the colloidal solution state, focusing on the role of pH and the size of satellite gold nanoparticles in determining the optical responses of nanoclusters.
研究成果
The study successfully demonstrates a one-pot assembly approach for controlling the architecture and optical response of core?satellite nanoclusters in the colloidal solution state. The pH of the assembly medium and the size of satellite AuNPs are key factors in determining the nanocluster architecture and its optical properties. These findings provide a foundation for the development of nanoclusters with predictable architectures and optical responses for applications in sensing, imaging, and therapy.
研究不足
The study is limited by the complexity of controlling the exact architecture of nanoclusters in the colloidal solution state and the need for further mechanistic understanding of the molecular forces leading to specific assembly architectures.
1：Experimental Design and Method Selection:
The study employs a one-pot assembly approach to create core?satellite nanoclusters, utilizing electrostatic interactions between amine-terminated silica nanoparticles (SiNPs) and citrate-capped gold nanoparticles (AuNPs). The pH of the assembly medium is varied to control the nanocluster architecture.
2：Sample Selection and Data Sources:
Amine-terminated SiNPs (60 nm diameter) and citrate-capped AuNPs (5, 10, and 15 nm diameter) are used as building blocks. The optical and morphological characteristics of the nanoclusters are analyzed using transmission electron microscopy (TEM) and optical spectroscopy.
3：List of Experimental Equipment and Materials:
TEM (FEI Tecnai G2 Twin), multimode microplate reader (FLUOstar Omega), Malvern Zetasizer Nano-S for ζ-potential measurements, and a hyperspectral transmission dark-field microscope from Cytoviva HSI for scattering measurements.
4：Experimental Procedures and Operational Workflow:
SiNPs and AuNPs are mixed under varying pH conditions, followed by PEGylation to ensure colloidal stability. The nanoclusters are then characterized for their morphology and optical properties.
5：Data Analysis Methods:
The optical response of nanoclusters is analyzed using COMSOL simulations to understand the plasmonic coupling between satellite AuNPs.
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Transmission electron microscope
FEI Tecnai G2 Twin
FEI
Used for morphological characterization of nanoparticles and nanoclusters.
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Gold chloride solution
5 mM
Sigma-Aldrich
Used as a precursor for gold nanoparticle synthesis.
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Citrate-capped gold colloid solutions
5 nm diameter, 10 nm diameter
BBI Solutions
Used as satellites in core?satellite nanoclusters.
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Sodium citrate
Sigma-Aldrich
Used as a reducing agent in the synthesis of gold nanoparticles.
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Hydrochloric acid
1 M
VWR
Used to adjust the pH of the assembly medium.
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Amine-terminated silica nanoparticles
60 nm diameter
Nanocomposix
Used as the core in core?satellite nanoclusters.
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Thiol-poly(ethylene glycol)
SH-PEG-COOH MW 3400
Nanocs Inc.
Used to ensure the colloidal stability of nanoclusters.
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Multimode microplate reader
FLUOstar Omega
BMG Labtech
Used for recording optical spectra of nanoparticles and nanoclusters.
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Zetasizer Nano-S
Malvern
Used for ζ-potential measurements of nanoparticles.
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Hyperspectral transmission dark-field microscope
Cytoviva HSI
Used for scattering measurements of nanoparticles and nanoclusters.
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