摘要： In some clinical applications, prior normal-dose CT (NdCT) images are available, and the valuable textures and structure features in them may be used to promote follow-up low-dose CT (LdCT) reconstruction. This study aims to learn texture information from the NdCT images and leverage it for follow-up LdCT image reconstruction to preserve textures and structure features. Specifically, the proposed reconstruction method first learns the texture information from those patches with similar structures in NdCT image, and the similar patches can be clustered by searching context features efficiently from the surroundings of the current patch. Then it utilizes redundant texture information from the similar patches as a priori knowledge to describe specific regions in the LdCT image. The advanced region-aware texture preserving prior is termed as ‘RATP’. The main advantage of the PATP prior is that it can properly learn the texture features from available NdCT images and adaptively characterize the region-specific structures in the LdCT image. The experiments using patient data were performed to evaluate the performance of the proposed method. The proposed RATP method demonstrated superior performance in LdCT imaging compared to the filtered back projection (FBP) and statistical iterative reconstruction (SIR) methods using Gaussian regularization, Huber regularization and the original texture preserving regularization.