研究目的
Investigating the one-pot preparation of physical hydrogel-based photonic crystal and its application in drug release.
研究成果
A direct strategy has been proposed for the preparation of 3D hydrogel-based photonic materials. The as-prepared GCCA sample showed pH dependent drug release properties whose diffraction color could also changed during the releasing process as the volume of the PVA/PEG hydrogel swelled or shrinked. Such hydrogel surrounding crystal array was robust and could be modified physically and/or chemically to make GCCA multi-sensitive.
研究不足
The common limitation of PCCAs and GCCAs is the long-term purification during preparation because of the ionic impurities could disturb the ordering of the assembled system.
1：Experimental Design and Method Selection:
A one-pot method for the fabrication of hydrogel-based photonic crystal (PC) materials was developed. The method involves self-assembling an array of monodisperse colloids within a polymer solution, which generates a visible light diffractable photonic mixture. This mixture was then molded and gelated into a hydrogel PC material by freeze-thaw treatment.
2：Sample Selection and Data Sources:
Monodisperse polystyrene (PS) spheres with a diameter of ca. 180 nm were prepared by emulsifier-free polymerization. Poly(vinyl alcohol) (PVA) and Poly(ethylene glycol) (PEG) were used as polymers.
3：List of Experimental Equipment and Materials:
Styrene (St), sodium hydrogen carbonate (NaHCO3), ammonium persulfate ((NH4)2S2O8), Poly(vinyl alcohol) (PVA), Poly(ethylene glycol) (PEG), Aspirin (ASP), ion-exchange resin, parafilm, and standard buffer solution with different pH values were used.
4：Experimental Procedures and Operational Workflow:
The PS latex was prepared, then PVA and PEG were stirred into the PS latex to form a homogeneous solution. The mixture was then subjected to a freezing-thawing cycle to form the GCCA.
5：Data Analysis Methods:
The optical properties of GCCA film were studied utilizing an Ocean Optics USB 4000-XR1-ES fiber optic spectrometer. The drug release was evaluated by UV/vis absorbance at 296 nm.
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