研究目的
To provide an overview of the principles and existing therapeutic platforms for HIFU, including US and MRI guidance, treatment planning, and monitoring capabilities, and to summarize current and potential future clinical applications.
研究成果
HIFU is a promising image-guided therapeutic modality with applications in treating a wide range of benign and malignant neoplasms. Ongoing clinical and translational investigation is needed to further validate and expand HIFU clinical applications.
研究不足
Technical challenges include the feasibility of treating large tumors within a finite treatment time, treating tumors prone to motion, and accessing targets when the acoustic window is restricted by intervening anatomy. The clinical efficacy based upon large-scale, prospective, randomized trials remains largely unproven for a broad spectrum of applications.
1：Experimental Design and Method Selection:
The chapter reviews the principles of HIFU, including its thermal and mechanical effects, and discusses the design of HIFU transducers and systems.
2：Sample Selection and Data Sources:
Clinical applications of HIFU in treating various benign and malignant neoplasms are discussed, with references to clinical trials and studies.
3：List of Experimental Equipment and Materials:
HIFU devices such as the Ablatherm, Sonablate 500, Model JC HIFU system, ExAblate system, and Sonalleve MR-HIFU are mentioned.
4：Experimental Procedures and Operational Workflow:
The chapter describes the process of HIFU treatment, including imaging guidance, treatment planning, and monitoring.
5：Data Analysis Methods:
The Sapareto–Dewey thermal dose model is mentioned for predicting tissue thermal damage.
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