研究目的
To assess the clinical usefulness and feasibility of collecting RNFL thickness using OCT in a memory unit from a large, consecutively recruited cohort.
研究成果
The study did not find significant differences in peripapillary RNFL thickness between cognitively healthy subjects, MCI, and AD patients, suggesting that RNFL thickness may not be a useful biomarker for cognitive impairment or AD. Further research should explore other OCT measurements in different retinal areas and layers.
研究不足
The study is cross-sectional, limiting conclusions about the dynamics of RNFL thinning. There was significant inter-individual variability within each group. The covariates considered might not fully control for inter-group variability.
1：Experimental Design and Method Selection:
The study was designed to assess differences in peripapillary RNFL thickness among cognitively healthy individuals, MCI, and AD patients using spectral domain OCT.
2：Sample Selection and Data Sources:
930 individuals (414 cognitively healthy individuals, 192 probable amnestic MCI and 324 probable AD) attending a memory clinic were consecutively included.
3：List of Experimental Equipment and Materials:
Spectral domain OCT (Maestro, Topcon) was used for examinations.
4：Experimental Procedures and Operational Workflow:
Participants underwent OCT examinations to measure RNFL thickness. Adjustments were made for age, education, sex, and OCT image quality.
5：Data Analysis Methods:
Multivariate adjusted analysis was performed to assess differences in RNFL thickness among groups.
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