研究目的
To develop a compact, handheld dermascope that enables real-time blood flow measurements of skin during conventional visual inspection, addressing the gap in robust quantification of functional information in skin lesion analysis.
研究成果
The LSCI-dermascope successfully enables simultaneous conventional visual inspection and blood flow measurements of skin lesions, demonstrating its potential to supplement structural information with functional data for improved lesion characterization.
研究不足
The study is a small pilot clinical study, and the LSCI-dermascope's ability to differentiate between more lesion types and its diagnostic accuracy compared to biopsies needs further investigation.
1：Experimental Design and Method Selection:
Integration of a compact laser speckle contrast imaging (LSCI) system into a custom-built dermascope for simultaneous blood flow measurements and conventional visual inspection.
2：Sample Selection and Data Sources:
In-vitro characterization using a tissue phantom and a small pilot clinical study involving cherry angiomas and solar lentigos.
3：List of Experimental Equipment and Materials:
Custom-built LSCI-dermascope, tissue phantom, Intralipid, syringe pump, and a CMOS camera.
4：Experimental Procedures and Operational Workflow:
Measurement of speckle contrast under various conditions (LED/room light on/off, handheld vs. mounted), characterization of response to varying flow rates, and in vivo validation.
5：Data Analysis Methods:
Computation of speckle contrast and speckle flow index (SFI) maps from acquired images, statistical analysis of blood flow differences between lesion types.
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current limiter
NSI45020
ON Semiconductor
Limiting current for white LEDs
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beam splitter
CM1-BS013
Thorlabs Inc.
Directing light for simultaneous imaging and visual inspection
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lens
59–872
Edmund Optics Inc.
Collimating LED light
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longpass dielectric filter
ET780lp
Chroma Inc.
Attenuating LED light
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lens
LB1596-A
Thorlabs Inc.
Magnifying LED light for visual inspection
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shortpass filter
FESH0700
Thorlabs Inc.
Filtering laser light for visual inspection
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CMOS camera
FireFly MV
FLIR Integrated Imaging Solutions, Inc.
Acquiring images for LSCI measurements
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white LEDs
SMLP12WBC7W1
Rohm Semiconductor
Illumination for conventional dermascope functionality
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laser diode
785MD-3-0610
LaserLands
Illumination for LSCI measurements
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