研究目的

Investigating the therapeutic effects of a specific herbal medicine on a particular disease.

研究成果

Making use of the halex exchange reaction as a key operation, [18F]-3 has been synthesized and identified unambiguously by calibration with its unlabelled counterpart synthesized previously through a different synthetic approach. Based on radioactive calculation among five region of interests, including brain, liver, heart, thigh muscle and kidney, [18F]-3 exhibited a very low uptake ratio (< 1%) in the brain, thus providing direct evidence to justify itself as a peripherally restricted CB1 antagonist. We believed that due to the synthetic simplicity and practicability of compound 3, this solid piece of work might provide a useful tool to further extend the horizon of metabolic knowledge associated with peripheral CB1 receptors in the future.

研究不足

The technical and application constraints of the experiments, as well as potential areas for optimization.