摘要： We present a highly sensitive detection of skin cancer using a novel water-based (THz) metamaterial (MM) used semiconductor film. We apply the application of terahertz pulsed imaging (TPI) in reflection geometry for the study of skin tissue and related cancers. As a refractive index (RI) sensing application of the proposed device, there will be shown with placing different sensing materials in the biosensor design, the effective RI will also change that in turn leads to measuring the sensitivity of the biosensor to detect the normal skin and Basal Cell Carcinoma (BCC). The RI FOM value of the proposed device is much higher than for the sensor using semiconductor film, to detect biomarkers in the literature. Significantly, the sensitivity increases by about 117 um/RIU and the RI FOM increases by more than 20.53. This results from a combination of size-related factors, leading to field enhancement accompanying strong field localization. We observed the resonance-frequency shift of the THz MM following the RI changing of the detected skin. The dip reflectance resonance has a blue-shift for normal skin. Finally, we suggest that this water-based MM can be used to control of the gene expression. The advantage of our design depends on two factors. Firstly, we used the MM structure, which has micro-scale, and the smaller the size of the structure, the more sensitive to the changes in the RI. Secondly, we used water in our structure, which is very well-suited to the human body and are highly bio-absorbable and inexpensive which is abundantly found in nature.