研究目的
To assess the potential impact of in-vivo corneal crosslinking (CXL) on the chemical composition of Intracorneal Rings Segments (ICRS).
研究成果
The study confirmed the polymerization of the ICRS material after in-vivo CXL treatment, suggesting a crosslinking reaction. This effect should be considered prior to any CXL treatment of post ICRS implanted cornea.
研究不足
The study was limited to the chemical analysis of ICRS material post CXL treatment, without assessing the biomechanical properties of the treated ICRS.
1：Experimental Design and Method Selection:
The study assessed the impact of CXL treatment on the chemical composition of ICRS using UV-Vis and FT-IR spectroscopy.
2：Sample Selection and Data Sources:
Three ICRS samples were extracted from patients' cornea who had undergone CXL treatment, and one sample from a patient who didn’t undergo CXL treatment was used as reference.
3：List of Experimental Equipment and Materials:
UV/VIS/NIR spectrophotometer (Perkin–Elmer, Lambda 900), ATR MIRacle accessorize in an IR EQUINOX55 spectrometer (Bruker, Germany), riboflavin solution, and PMMA rings.
4：Experimental Procedures and Operational Workflow:
The extracted ICRS samples were rinsed with sterile balance salt solution (BSS), dried, and then subjected to spectroscopic measurements.
5：Data Analysis Methods:
The spectra of ICRS samples were analyzed for alterations in the chemical structure, focusing on the 2800 to 3200 cm-1 spectral region.
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UV/VIS/NIR spectrophotometer
Lambda 900
Perkin–Elmer
Used for obtaining UV-Vis absorption spectra of the samples.
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ATR MIRacle
PIKE technologies
Used for acquiring FT-IR spectra of the samples.
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IR EQUINOX55 spectrometer
Bruker
Used in conjunction with ATR MIRacle for FT-IR spectroscopic analysis.
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IntraLase Femtosecond Laser
60 Megahertz
IntraLase, Irvine, California, USA/ AMO's IntraLase? FS Technology
Used for laser-assisted placement of ICRS.
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Keraring
SI-6
Kerarig Mediphacos - Ophthalmic
Intracorneal Ring Segments used in the study.
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Peschke Meditade GmbH UV-X crosslinking system
Used for corneal CXL treatment.
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