研究目的
Investigating the synthesis of imidazo fused quinazoline under UV-light intervention and its solvatochromism, antioxidant, antifungal, and luminescence properties.
研究成果
The photochemical method efficiently synthesized benzo[4,5]imidazo[2,1-b]quinazoline with high yield. The compound exhibited significant solvatochromism, antioxidant, and antifungal activities, suggesting potential applications in medicinal chemistry and material science.
研究不足
The study is limited by the specific conditions required for UV-light mediated synthesis and the scope of biological activities tested.
1：Experimental Design and Method Selection:
The photochemical synthesis of benzo[4,5]imidazo[2,1-b]quinazoline was conducted under UV irradiation (>360 nm) using KOH/DMF as a base and solvent.
2：Sample Selection and Data Sources:
The reaction involved 3,4-dihydronaphthalen-1(2H)-one and 1H-benzo[d]imidazol-2-amine.
3：List of Experimental Equipment and Materials:
UV-visible photo reactor, TLC for product confirmation, NMR, and HRMS for analysis.
4：Experimental Procedures and Operational Workflow:
The reaction mixture was illuminated for 10 mins at 555 nm, followed by purification via column chromatography.
5：Data Analysis Methods:
The synthesized compound was analyzed for solvatochromism, antioxidant activity (DPPH and H2O2 methods), and antifungal activity against Aspergillus species.
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