研究目的
Investigating the design and implementation of a reusable-tapered optical fiber sensor (RFS) to analyze the metastability of colloidal gold nanoparticles in the presence of glucose and insulin.
研究成果
The RFS effectively detected changes in the stability and refractive index of MAuNPs solutions upon addition of glucose and insulin. Glucose stabilized MAuNPs, while insulin triggered their aggregation. Raman spectroscopy provided insights into the chemical interactions between MAuNPs and the biomolecules. The study demonstrates the potential of RFS in analyzing nanoparticle stability and biomolecule interactions.
研究不足
The study was limited by the optical transparency of glucose and insulin to visible light, which affected the RFS's ability to detect these biomolecules directly without MAuNPs. Additionally, the specific mechanisms of glucose and insulin interactions with MAuNPs require further investigation.
1：Experimental Design and Method Selection:
The study involved the design and fabrication of a reusable-tapered optical fiber sensor (RFS) to analyze the metastability of gold nanoparticles. The methodology included the use of a white light source and Raman spectroscopy for chemical interaction studies.
2：Sample Selection and Data Sources:
Metastable gold nanoparticles (MAuNPs) were synthesized and characterized. The samples included MAuNPs, glucose, and insulin mixtures.
3：List of Experimental Equipment and Materials:
Equipment included a Laser splicer system (LZM-100) for taper fabrication, a white light source (YOKOGAWA, M-AQ4305), and a hollow core photonic crystal fiber (HC-PCF) for Raman spectroscopy.
4：Experimental Procedures and Operational Workflow:
The RFS was used to detect changes in the refractive index and stability of MAuNPs upon addition of glucose and insulin. Raman spectroscopy was employed to study chemical interactions.
5：Data Analysis Methods:
Changes in the absorption spectra and Raman signals were analyzed to determine the effects of glucose and insulin on MAuNPs stability and interactions.
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