研究目的
To develop a CAD method for assessing the bone age of children from a hand and wrist radiograph, replacing the outdated Greulich and Pyle (G&P) Atlas with a more accurate and ethnically diverse Digital Hand Atlas (DHA).
研究成果
The developed CAD method for bone age assessment using a digital hand atlas provides a more accurate and ethnically diverse standard compared to the outdated G&P Atlas. The system aids radiologists in performing BAA by offering a consistent second opinion, though adjustments may be needed for older children.
研究不足
The CAD method may underestimate the ages of children older than 8–10 years and overestimate the ages of children younger than 8–9 years compared with radiologists’ assessments. The wrist joint bone assessment is more difficult for the CAD to perform due to the requirement of good image quality to distinguish the joint space.
1：Experimental Design and Method Selection:
The study involved the development of a CAD system using a digital hand atlas for bone age assessment. The methodology included image processing algorithms and fuzzy logic for computing bone age.
2：Sample Selection and Data Sources:
Over 10 years, 1390 hand and wrist radiographs of healthy and normal Asian, African American, Caucasian, and Hispanic boys and girls aged 1–18 years were collected from public schools in Los Angeles County, California.
3：List of Experimental Equipment and Materials:
Equipment included an x‐ray generator (Polyphos 50; Siemens, Erlangen, Germany) and a laser film digitizer (Model 2905, Array Corporation, Tokyo, Japan).
4：Experimental Procedures and Operational Workflow:
Each radiograph was obtained using a strict protocol, digitized into DICOM format, and analyzed by two experienced pediatric radiologists.
5：Data Analysis Methods:
Statistical analyses were performed using SPSS, version 15.0 for Windows, and graphs were generated by KaleidaGraph, Synergy Software.
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