研究目的
To develop a one-step strategy for the in situ synthesis of highly water-dispersable NaYF4:Yb/Er upconversion nanoparticles (UCNPs) functionalized with dicarboxylic acids for bioimaging applications.
研究成果
The study successfully developed a one-step strategy to in situ synthesize size- and phase-controlled water-dispersible NaYF4:Yb/Er UCNPs functionalized with adipic acid. The UCNPs exhibited minimal cytotoxicity and high quality for in vitro imaging under NIR light excitation, indicating their potential for biological applications.
研究不足
The study focuses on the synthesis and bioimaging application of NaYF4:Yb/Er UCNPs functionalized with dicarboxylic acids, with adipic acid showing superior performance. However, the study does not explore the full range of potential dicarboxylic acids or their effects on UCNP properties in depth.
1：Experimental Design and Method Selection:
A solvothermal method was employed to synthesize NaYF4:Yb/Er UCNPs functionalized with different dicarboxylic acids.
2：Sample Selection and Data Sources:
A series of dicarboxylic acids (succinic acid, adipic acid, suberic acid, and sebacic acid) were selected to functionalize the UCNPs.
3：List of Experimental Equipment and Materials:
Materials included Y(NO3)3?6H2O, Yb(NO3)3?5H2O, Er(NO3)3?5H2O, succinic acid, adipic acid, suberic acid, sebacic acid, NaF, NaNO3, NH4F, hexane, Ethylene glycol (EG), and DMSO. Equipment included a JEOL (JEM-1400) electron microscope, JEOL JSM-6700F field emission scanning electron microscopy, Horiba JobinYvon FluoroMax-4 system, Bruker D8-Advance X-Ray Diffractometer, and Perkin Elmer Spectrum GX.
4：Experimental Procedures and Operational Workflow:
The synthesis involved dissolving dicarboxylic acids in EG, adding Y(NO3)3?6H2O, Yb(NO3)3?5H2O, Er(NO3)3?5H2O, and NaF, agitating the mixture, transferring it into an autoclave, and solvothermally treating it at 180 ℃ for 8 h.
5：Data Analysis Methods:
The products were characterized using TEM, SEM, XRD, and FTIR.
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