研究目的
Investigating the therapeutic effects of Vapreotide-Mediated Hierarchical Mineralized Au/Ag nanoshells on photothermal anti-tumor therapy.
研究成果
Vap@Ag/AuNSs exhibit excellent photothermal conversion efficiency, biocompatibility, and tumor-targeting capabilities, making them promising candidates for photothermal tumor therapy. The study demonstrates the potential of polypeptide-directed synthesis for creating effective nanotherapeutic agents.
研究不足
The study primarily focuses on in vitro evaluation of Vap@Ag/AuNSs. Further in vivo studies are needed to confirm the therapeutic efficacy and biocompatibility in a more complex biological environment.
1：Experimental Design and Method Selection
The study involved the synthesis of Vap@Ag/AuNSs via a galvanic replacement reaction between Vap-templated Ag nanocages (Vap-AgNCs) and HAuCl4. The methodology included polypeptide-directed mineralization and hierarchical self-assembly under mild conditions.
2：Sample Selection and Data Sources
Vapreotide acetate (Vap) was used as a biotemplate. Silver nitrate (AgNO3) and gold chloride (AuCl3) were used as precursors for the synthesis of Ag/Au bimetallic nanoshells.
3：List of Experimental Equipment and Materials
UV-Vis spectroscopy (WFZ-26A spectrometer), TEM (Hitachi-7650 and JEOL JEM-2010), EDS, XRD, Zetasizer Nano-ZS90 (Malvern, UK), NIR emitter (MDL-N-808 nm-10 W, Changchun New Industry Photoelectric, China).
4：Experimental Procedures and Operational Workflow
The synthesis involved the reduction of AgNO3 to Ag using sodium borohydride, followed by the addition of HAuCl4 to form Vap@Ag/AuNSs. The nanoparticles were characterized for size, morphology, and photothermal properties.
5：Data Analysis Methods
Photothermal conversion efficiency was calculated using temperature variation data. Biocompatibility was assessed via MTT assay, and photothermal therapy efficacy was evaluated using fluorescein diacetate staining.
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