研究目的
To model and simulate a 3D label free Nano Amperometric Biosensor for the early diagnosis of cancerous cells with sustainable interfacial coefficients.
研究成果
The study successfully models and simulates a 3D label free Nano Amperometric Biosensor for early diagnosis of cancerous cells. The developed equations and simulations can be used to fabricate the device for healthcare applications, providing a method to distinguish between cancerous and non-cancerous cells based on current measurements.
研究不足
The study focuses on the modeling and simulation aspects, and the actual fabrication and testing of the biosensor in clinical settings are not covered. The interfacial coefficients need to be carefully adjusted to ensure no change in biosensor action under stress.
1：Experimental Design and Method Selection:
The study involves the modeling and simulation of a 3D label free Nano Amperometric Biosensor using Glucose Oxidase (GODx) as the biological element and hydrogen peroxide (H2O2) and cancerous blood as the analyte. The process involves Direct Current Cyclic Voltammetry to measure the current in milliamperes corresponding to the oxygen released.
2：Sample Selection and Data Sources:
The analyte used includes hydrogen peroxide (H2O2) and cancerous blood. The biological element is Glucose Oxidase (GODx).
3：List of Experimental Equipment and Materials:
The biosensor consists of outer and semipermeable membranes, three electrodes (working, reference, and counter electrodes), and uses Carbon Nano Tubes (CNT) as electrodes due to their electrical conductivity and eco-friendliness.
4：Experimental Procedures and Operational Workflow:
The biosensor action starts when the substrate appears in bulk solution. A fixed potential is applied between counter and reference electrodes, and the potential between working and counter electrode is varied to measure current in milliamperes.
5：Data Analysis Methods:
The study involves mathematical modeling and simulation using MATLAB for analyzing the variation of current versus diffusion coefficient (De).
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