摘要： We report the first-in-human images with any hybrid imaging catheter combining intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The catheter has a 2.8-F imaging window with a 40-MHz center frequency for IVUS imaging. The IVUS and OCT beams are aligned with each other, allowing inherent coregistration and immediate simultaneous image review. Imaging was performed in a 74-year-old male patient with a recent inferior ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention in the distal right coronary artery. Imaging was performed over 90 mm of the right coronary artery at a pull-back speed of 25 mm/s, with contrast flushing at 3 ml/s for 5 s. Figure 1 highlights the complementary roles of IVUS and OCT to characterize atherosclerotic plaque types. A nonculprit lesion was present in the mid left anterior descending coronary artery. Staged intervention was performed with implantation of a Promus 2.75 × 20 mm (Boston Scientific, Natick, Massachusetts) stent. Imaging was performed after stent implantation over a 70-mm length at a pull-back speed of 25 mm/s and contrast flush at 4 ml/s for 4 s. Imaging findings in the left anterior descending coronary artery and D1 are shown in Figure 2. The imaging pull-back shows a dissection distal to the left anterior descending coronary artery stent. Near-field findings of dissection and stent apposition are better appreciated on OCT, while deeper features such as side branches and plaque burden are better assessed on IVUS. This first in vivo experience of hybrid IVUS and OCT demonstrates the synergistic ability of these modalities to characterize coronary atherosclerosis and coronary interventions.