研究目的
To explore the use of supra-CNDs as a photothermal agent for photothermal therapy (PTT) and a contrast agent for photoacoustic (PA) imaging in vivo.
研究成果
Supra-CNDs have been successfully explored as photothermal agents for PTT and contrast agents for PA imaging. In vivo tumor PTT was realized under 655 nm laser irradiation via intratumor injection of supra-CNDs. The supra-CNDs can accumulate in tumor tissue after intravenous injection, and in vivo PTT after intravenous injecting supra-CNDs prolonged the life of mice due to tumor growth inhibition. These properties indicate that supra-CNDs can be used as biomedical agents for PA imaging and tumor therapy.
研究不足
The study was conducted on mice, and further research is needed to confirm the efficacy and safety of supra-CNDs in humans. The absorption of supra-CNDs in the red to NIR region could be further optimized.
1：Experimental Design and Method Selection:
The study involved the synthesis of supra-CNDs and their application in PTT and PA imaging. The photothermal performance of supra-CNDs was examined under different concentrations and laser power densities.
2：Sample Selection and Data Sources:
Female ICR mice with H22 tumors were used for in vivo PTT and PA imaging experiments.
3：List of Experimental Equipment and Materials:
HRTEM for morphology investigation, UV–vis spectrophotometer for absorption spectra, laser for irradiation, thermal imaging camera for temperature monitoring, and a custom-built acoustic-resolution photoacoustic microscopy system for PA imaging.
4：Experimental Procedures and Operational Workflow:
Supra-CNDs were synthesized, characterized, and then used in vivo for PTT and PA imaging. The temperature changes and tumor growth rates were monitored.
5：Data Analysis Methods:
Statistical analysis was performed using one-way ANOVA test to assess differences between groups.
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