研究目的
Investigating the effects of visible light on inducing pigmentation in human skin and the protective role of formulations containing yellow iron oxide (YIO) against such pigmentation.
研究成果
The study demonstrated that visible light induces pigmentation in human skin, which can be mitigated by formulations containing yellow iron oxide. An in vitro model was developed to predict the protective effectiveness of such formulations, showing good agreement with in vivo results. This approach could be fundamental in preventing skin pigmentary disorders.
研究不足
The study was limited to subjects with Fitzpatrick skin phototypes IV to VI. The in vitro model's predictive accuracy for other skin types or under different conditions was not explored.
1：Experimental Design and Method Selection:
Developed an in vitro absorption method to determine the protection provided by a test formulation containing 4.5% YIO using an IPD UVA-VIS action spectrum. Conducted an in vivo study with 10 normal healthy volunteers with Fitzpatrick skin phototypes IV to VI to verify the predictive model.
2：5% YIO using an IPD UVA-VIS action spectrum. Conducted an in vivo study with 10 normal healthy volunteers with Fitzpatrick skin phototypes IV to VI to verify the predictive model.
Sample Selection and Data Sources:
2. Sample Selection and Data Sources: Enrolled subjects were in general good health and prescreened on the basis of Fitzpatrick skin type prior to enrollment.
3：List of Experimental Equipment and Materials:
Used a Fiber-Lite Model 180 light source, Spectroradiometer OL-756, Newport Multi-Function Optical Meter Model 1835-C, and a formulation containing 4.5% Yellow Iron Oxide (YIO).
4：5% Yellow Iron Oxide (YIO).
Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: Subjects were exposed to visible light with and without the protective formulation. Pigmentation was assessed by visual exam, diascopy exam, and cross-polarized photography.
5：Data Analysis Methods:
The absorption spectrum of the formulation was measured, and the protection factor was calculated using the proposed IPD action spectrum.
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