研究目的
To explore the efficient synthesis of the all-thiophene-based double helix, DH-1, and study its crystal structure, chiral resolution, and chiroptical property.
研究成果
The all-thiophene-based double helix DH-1 was successfully synthesized and characterized. Its crystal structure, chiral resolution, and chiroptical properties were studied. Arylation at the central COTh unit was achieved, but further functionalization to create a two-dimensional cross-double helix remains a challenge.
研究不足
The synthesis yield of DH-1 was low (10-35%), and attempts to synthesize a cross-double helix, DH-5, were unsuccessful due to torsional strain.
1：Experimental Design and Method Selection:
The synthesis of DH-1 involved selective deprotonation of COTh followed by Negishi coupling reaction with 3,3′-bithiophene.
2：Sample Selection and Data Sources:
COTh and 3,3′-bithiophene were used as starting materials.
3：List of Experimental Equipment and Materials:
THF, n-BuLi, ZnCl2, Pd(PPh3)4, and other reagents were used.
4：Experimental Procedures and Operational Workflow:
The reaction was carried out under inert atmosphere, followed by purification via column chromatography.
5：Data Analysis Methods:
NMR, HRMS, IR, and X-ray crystallography were used for characterization.
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