研究目的
To evaluate the microbial toxicity and stability of HfO2 and ZrO2 nanoparticles coated with benzoate, isobutyrate, or methacrylate ligands in various bioassay media.
研究成果
The coated HfO2 and ZrO2 NPs showed low to moderate toxicity to A. fischeri but were harmless to aerobic heterotrophs and methanogens at high concentrations. The NPs are unlikely to cause acute microbial toxicity at environmentally relevant concentrations.
研究不足
The study focused on acute toxicity and did not assess long-term effects or environmental fate beyond the experimental conditions. The aggregation of NPs in bioassay media may not fully represent their behavior in natural environments.
1：Experimental Design and Method Selection:
The study involved assessing the stability of NP dispersions through zeta potential, particle size distribution, and leaching analyses, and evaluating their toxicity towards different microbial populations.
2：Sample Selection and Data Sources:
NPs were characterized using thermogravimetric and differential thermal analysis, and dynamic light scattering. Microbial toxicity was assessed using A. fischeri, anaerobic granular sludge, and aerobic heterotrophs.
3：List of Experimental Equipment and Materials:
Equipment included a Seiko Instruments TD/DTA 6200, Malvern Zetasizer Nano, Microtox? Model 500 analyzer, and gas chromatography systems.
4：Experimental Procedures and Operational Workflow:
NPs were dispersed in various media, and their stability and toxicity were measured. Microbial inhibition was assessed through specific bioassays.
5：Data Analysis Methods:
Specific activities and normalized activities were calculated to determine microbial inhibition. IC50 values were calculated for toxicity assessment.
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