研究目的
Investigating the therapeutic effects of nanoscale metal?organic layers (nMOLs) based on Hf12 and Hf6 secondary building units (SBUs) and photosensitizing Ir(bpy)[dF(CF3)ppy]2+ derived ligands for radiotherapy (RT) and radiodynamic therapy (RDT) in cancer treatment.
研究成果
The study demonstrates that Hf12-Ir and Hf6-Ir nMOLs can effectively enhance RT and elicit RDT through the generation of hydroxyl radicals, singlet oxygen, and superoxide anions upon X-ray irradiation. These nMOLs represent a novel class of 2D materials with great potential for cancer treatment, achieving >99% tumor regression at low X-ray doses.
研究不足
The study is limited by the difficulty in the synthesis of stable, functional, and nonaggregated nMOLs. Potential areas for optimization include improving the stability and scalability of nMOLs for clinical applications.
1：Experimental Design and Method Selection:
The study involved the synthesis of Hf12-Ir and Hf6-Ir nMOLs through solvothermal reactions, characterization of their structures and morphologies using TEM, AFM, and PXRD, and evaluation of their RT-RDT capabilities through in vitro and in vivo experiments.
2：Sample Selection and Data Sources:
MC38 cells and MC38-tumor bearing C57BL/6 mice were used as models.
3：List of Experimental Equipment and Materials:
Transmission electron microscopy (TEM), atomic force microscopy (AFM), powder X-ray diffraction (PXRD), inductively coupled plasma mass spectrometry (ICP-MS), confocal microscopy, and electron paramagnetic resonance (EPR) were used.
4：Experimental Procedures and Operational Workflow:
The nMOLs were synthesized, characterized, and their therapeutic effects were evaluated through ROS generation assays, cytotoxicity assays, and tumor regression studies.
5：Data Analysis Methods:
Data were analyzed using fluorescence assays, EPR spectroscopy, and statistical analysis of tumor regression.
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