研究目的
To evaluate the diagnostic ability of macular ganglion cell complex (mGCC) and macular ganglion cell inner plexiform layer (mGCIPL) measurements in glaucoma using swept source optical coherence tomography.
研究成果
The study concluded that both mGCC and mGCIPL measurements using swept source OCT have high diagnostic accuracy, sensitivity, and specificity for glaucoma. However, mGCC thickness measurement was more effective in detecting early glaucomatous changes compared to mGCIPL.
研究不足
The study had a relatively small sample size and included a range of glaucoma severities without detailed subgroup analysis. Additionally, patients with other macular diseases were excluded, which may limit the generalizability of the findings to all glaucoma patients.
1:Experimental Design and Method Selection:
The study assessed the average and sectional thickness of mGCC and mGCIPL in 109 eyes using swept source OCT to compare differences among advanced stage glaucoma, early stage glaucoma, and normal groups.
2:Sample Selection and Data Sources:
109 eyes of 109 subjects were selected from August 2014 to July 2015, with measurements taken using DRI OCT-
3:List of Experimental Equipment and Materials:
Deep Range Imaging OCT-1 (Topcon Co., Tokyo, Japan) was used for measurements.
4:Experimental Procedures and Operational Workflow:
Measurements of mGCC and mGCIPL thickness were compared with cpRNFL thickness for diagnostic accuracy, sensitivity, and specificity.
5:Data Analysis Methods:
Statistical analysis was performed using SPSS version 14.0 and R 3.1.3, with AUC, sensitivity, and specificity calculated for diagnostic accuracy.
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