研究目的
Investigating the synthesis and properties of luminescent mercaptoimidazole-capped copper nanoclusters (CuNCs) with substituent driven self-assembly and aggregation induced emission (AIE).
研究成果
A novel synthetic procedure of copper nanoclusters utilizing imidazole based bidentate ligands was reported. The effect of substituents on their self-assembly and photophysical properties was addressed. The aggregation induced emissions of the nanoclusters were found to be highly stable in both solution and the solid state. These nanoclusters were found to be non-toxic and retained their aggregation induced emission in human cells, which can be further exploited for bio-sensing and delivery applications.
研究不足
The poor solubility of these clusters in water/acetonitrile makes it difficult to analyse them through electrospray ionisation mass spectrometry (ESI-MS).
1：Experimental Design and Method Selection:
The synthesis was carried out via reaction of copper sulphate pentahydrate (CuSO4·5H2O) with 2-mercaptoimidazole (MI) in the presence of hydrazine hydrate as a reducing agent. A variety of copper salts, reducing agents, and solvent systems were utilized to standardise a facile one-pot synthetic procedure.
2：Sample Selection and Data Sources:
Different substituents on MI were introduced to study their effects on the AIE of CuNCs.
3：List of Experimental Equipment and Materials:
Copper salts (CuSO4·5H2O, CuCl2 and CuI), reducing agents (NaBH4, hydrazine hydrate, and hydroxylamine), and solvent systems (methanol and acetonitrile) were used.
4：Experimental Procedures and Operational Workflow:
The optimised ratio of the ligand, CuSO4·5H2O, and hydrazine hydrate (1 : 1 : 10) resulted in highly stable luminescent CuNCs.
5：Data Analysis Methods:
The composition of CuNCs was determined by MALDI-TOF mass spectrometry. The oxidation state of copper was determined by XPS. The self-assembly/aggregation of CuNCs was studied using SEM and TEM.
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