研究目的
To develop and evaluate an imaging needle capable of intraoperatively detecting blood vessels during neurosurgery to minimize the risk of intracranial hemorrhage.
研究成果
The imaging needle demonstrated high sensitivity and specificity in detecting blood vessels intraoperatively, suggesting its potential to reduce hemorrhagic complications in neurosurgical procedures. This technology represents a significant advancement in real-time, intraoperative imaging for neurosurgery.
研究不足
The primary limitation is the small penetration depth of approximately 1 to 1.5 mm in optically scattering tissue, which may restrict the detection of deeper vessels. Additionally, the study's sample size was limited to 11 patients.
1：Experimental Design and Method Selection:
The study involved the development of an imaging needle integrating a miniaturized optical coherence tomography (OCT) probe for real-time blood vessel detection during neurosurgery.
2：Sample Selection and Data Sources:
Eleven patients undergoing craniotomy for various indications were enrolled. Data included 160 measurements from surface blood vessels and control sites.
3：List of Experimental Equipment and Materials:
A custom-built imaging stylet with an OCT probe, integrated into a standard clinical brain biopsy needle, was used alongside a spectral-domain OCT system.
4：Experimental Procedures and Operational Workflow:
The imaging needle was used to scan surface and deep blood vessels, with OCT measurements compared against a gold standard of intraoperative photographs.
5：Data Analysis Methods:
An automated algorithm analyzed OCT speckle decorrelation to differentiate vascular from nonvascular tissue, with statistical analysis performed to assess accuracy.
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