研究目的
To demonstrate the importance of PAT, the considerations of selecting an instrument for the task at hand, and the ability of rapid prototyping to allow new analytical processes to be explored.
研究成果
Students gained a strong understanding of PAT, the strengths and weaknesses of the two PAT techniques explored, and how 3D printing can aid in experimental design. The exercise demonstrated the practical value of introducing students to the fundamentals of PAT and the benefits of rapid prototyping in scientific procedures.
研究不足
The reaction had not gone to completion within the laboratory exercise, and students suggested providing data from a previous run that shows the reaction going to completion.
1：Experimental Design and Method Selection:
The experiment involved monitoring an amide bond formation reaction using flow UV?vis spectroscopy and mass spectrometric analysis.
2：Sample Selection and Data Sources:
The reaction between para-substituted aniline p-(N,N-Dimethylamino)aniline (1) with benzoyl chloride (2) to form amide 3 was monitored.
3：List of Experimental Equipment and Materials:
Included an LTQ XL ion trap mass spectrometer, a Cary 50 UV?vis spectrometer, fused silica lines, unions assemblies, and 3D printed parts.
4：Experimental Procedures and Operational Workflow:
The reaction was monitored in real-time with the instruments coupled via 3D printed parts.
5：Data Analysis Methods:
UV?vis spectra and mass spectra were analyzed to monitor the reaction progress.
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