摘要： A novel three-dimensional microporous framework, [Tb(pddb)phen(ox)0.5]n (Tb-MOF), was synthesized hydrothermally with V-shaped 4,4′-(pyridine-2,6-diyl)-dibenzoic acid (H2pddb), oxalate (ox), and 1,10-phenanthroline (phen). The framework of Tb-MOF features one-dimensional channels functionalized with pyridine-N Lewis base groups and the absence of coordinated and lattice water molecules in the structure. The Tb-MOF exhibits high thermostability (up to 385 °C) and chemical stability in a wide pH range (4?11) and common organic solvents as well as boiling water. The luminescence investigations of the Tb-MOF in common solvents, water with di?erent pH values, and inorganic ions were performed. Results show that the Tb-MOF has high luminescence stability and the ability to probe Fe3+ ions. Signi?cantly, the Tb-MOF with particularly high water stability can be ?rst developed as a highly selective and sensitive luminescent sensor for the biomarker 2-thiazolidinethione-4-carboxylic acid (TTCA) via ?uorescence quenching. The low detection limit (1 ppm), reusability, and high antidisturbance together make the Tb-MOF become a promising sensor for the practical detection of TTCA in urine systems, and for the ?rst time realize the detection of urinary TTCA through ?uorescence spectrometry based on an Ln-MOF sensor.