摘要： We aim to investigate the counting response variations of Positron Emission Tomography (PET) scanners with different detector configurations in the presence of Solitary Pulmonary Nodule (SPN). Using experimentally validated Monte Carlo simulations, the counting performance of four different scanner models with varying tumor activity, location, and patient obesity is represented using NECR (Noise Equivalent Count Rate). NECR is a well-established quantitative metric which has positive correlation with clinically perceived image quality. The combined effect of tumor displacement and increased activity shows a linear ascending trend for NECR with slope ranges of (12.5–18.2)*10-3 (kBq/cm3)-1 for three-ring (3R) scanners and (15.3–21.5)*10-3 (kBq/cm3)-1 for four-ring (4R). The trend for the combined effect of tumor displacement and patient obesity is exponential decay with 3R configurations weakly dependent on the patient obesity if the tumor is located at the center of the field-of-view with exponent’s range of (6.6-33.8)*10-2 cm-1. The dependency is stronger for 4R scanners (9.6–38.5)*10 -2 cm-1. The analysis indicates that quantitative PET data from the same SPN patient possibly examined in different time points (e.g. during staging or for the evaluation of treatment response) are affected by the different detector configurations and need to be normalized with patient weight, activity, and tumor location to reduce unwanted bias of the diagnosis. Our work provides also with a proof of concept for the ability of properly tuned simulations to provide additional insights into the counting response variability especially in tumor types where often borderline decisions have to be made regarding their characterization.