研究目的
To develop and utilize a simple kinetic simulation model for estimating protein drug concentrations in the vitreous and aqueous humor after intravitreal injections and controlled release administration, and to demonstrate its accuracy and utility in designing ocular delivery systems for biologicals.
研究成果
The simple kinetic model accurately predicted the concentrations of biologicals in the vitreous and aqueous humor after intravitreal injections, demonstrating almost complete anterior segment bioavailability and significant dose sparing with controlled release systems. It is a useful tool for designing intraocular delivery systems, though it has limitations regarding molecule type and lack of gradient or pharmacodynamic simulations.
研究不足
The model is limited to biologicals and large molecules with insignificant permeation across blood-ocular barriers; it only simulates mean concentrations in the vitreous and aqueous humor, not concentration gradients; it does not include pharmacodynamics or distribution to cells or tissues; and the drug release rate in the model may differ from in vitro rates.
