研究目的
To report the use of indocyanine green (ICG)-based angiography to determine the blood flow in patients with peripheral arterial disease (PAD) and vascular trauma, as there is no widely accepted standard for intraoperative measurement of tissue perfusion.
研究成果
ICG angiography can determine surface tissue viability in PAD patients with ischemic wounds and guide revascularization therapy in claudicants. In vascular trauma cases, it helps assess tissue perfusion for wound closure decisions. Further studies are needed to define its utility in assessing perfusion, response to revascularization, and predicting wound healing likelihood.
研究不足
The SPY technology is limited to perfusion information at a depth of 5 mm, providing data only on the superficial capillary system and not deep tissue perfusion. Patients allergic to iodine, sulfa, or penicillin should be excluded. It is not known whether ICGA provides the same or higher level of sensitivity and specificity as other nonvascular measurements.
1：Experimental Design and Method Selection:
The study utilized the SPY fluorescent imaging system for intraoperative ICG angiography to assess tissue perfusion in patients with PAD and vascular trauma. The method involved intravenous injection of ICG followed by imaging to quantitatively evaluate perfusion before and after revascularization or wound closure.
2：Sample Selection and Data Sources:
Five consecutive patients were selected: four with PAD (three with critical limb ischemia and one with severe claudication) and one with vascular trauma from a traffic accident. Data were collected during surgical procedures.
3：List of Experimental Equipment and Materials:
SPY fluorescent imaging system (Novadaq Corp.), ICG (2.5 mg/mL), normal saline, intravenous injection supplies.
4：5 mg/mL), normal saline, intravenous injection supplies.
Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: The SPY system was positioned at an optimal distance from the tissue. ICG (3-5 mL) was injected intravenously, followed by a 10-mL saline flush. Imaging was performed to capture perfusion data. For PAD patients, imaging was done before and after revascularization; for trauma, before wound closure.
5：Data Analysis Methods:
Perfusion was assessed quantitatively using the SPY system's imaging capabilities, with visual and objective measurements of tissue viability and blood flow changes.
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