研究目的
To assess the RNFL thickness and compare its correlation with refractive status and axial length of the eye.
研究成果
The study showed that RNFL thickness measured by 3D OCT is affected by refractive status and axial length, with hyperopia increasing and myopia decreasing thickness, especially beyond 3D. This suggests that normative databases should account for refractive status to improve diagnostic accuracy in glaucoma and other optic nerve diseases.
研究不足
Exclusion of subjects with astigmatism higher than 1.00 D, corneal disorders, retinal and optic disc diseases, glaucoma, and previous ocular surgery or trauma may limit generalizability. The study is cross-sectional and does not establish causality. Potential for observer bias as images were captured by a single observer.
1：Experimental Design and Method Selection:
Subjects were divided into 5 groups based on refractive error (emmetropia, low hyperopia, high hyperopia, low myopia, high myopia). RNFL analysis was performed using TOPCON 3D OCT-2000 with fast RNFL thickness
2：4 scanning protocol. Analysis of variance (ANOVA) was used to assess significance between groups. Sample Selection and Data Sources:
300 eyes of 150 subjects aged 20-40 years, selected using systemic random sampling, excluding those with certain ocular conditions.
3：List of Experimental Equipment and Materials:
TOPCON 3D OCT-2000, IOL master for axial length measurement, 1% tropicamide and 5% phenylephrine eye drops for dilation, statistical software (SAS
4：2, SPSS 0, Stata 1, MedCalc 1, Systat 0, R environment ver.1). Experimental Procedures and Operational Workflow:
Subjects underwent clinical examination including refractive error measurement, visual acuity, slit lamp exam, tonometry, fundoscopy, and axial length measurement. Eyes were dilated, and OCT scans were performed with internal fixation, repeated to ensure good image quality based on signal-to-noise ratio and subjective color assessment.
5：Data Analysis Methods:
Descriptive statistics, ANOVA at 5% significance level, using various statistical software for data analysis.
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