研究目的
To design and analyze a novel multimode surface plasmon resonance biosensor with highly dispersion tailored properties using Te?on and metamaterial layers for improved biorecognition.
研究成果
The proposed multimode SPR sensor design, assisted by Te?on and metamaterial layers, achieves highly dispersion tailored properties, enabling efficient biorecognition by removing side lobes in dispersion graphs and supporting up to five modes. It offers improved sensitivity and differentiation between surface and bulk effects, bridging the gap to real-world biosensing applications.
研究不足
Experimental validation of metamaterial layers at optical frequencies is not possible due to fabrication challenges. The study relies on simulations and available experimental data for dual-mode sensors, limiting full experimental verification of the proposed multimode design.
1：Experimental Design and Method Selection:
The study uses the transfer matrix method to model and calculate reflectance, group delay, and group velocity dispersion for the SPR sensor. A multilayer structure with Te?on, gold, metamaterial, and silver layers is designed to achieve multimode operation.
2：Sample Selection and Data Sources:
Simulations are performed for various solvents (air, water, lecithin, deoxygenated hemoglobin) with refractive indices specified at 633 nm wavelength. Experimental validation uses fabricated samples with SF-10 glass, Te?on AF layer, and gold layer.
3：List of Experimental Equipment and Materials:
Equipment includes sputtering system for gold deposition, spin coater for Te?on, ellipsometer for thickness measurement. Materials include SF-10 glass, Te?on AF, gold, metamaterial, silver, SAM layer, and solvents.
4：Experimental Procedures and Operational Workflow:
Fabrication involves cleaning SF-10 glass, spin coating Te?on at 3500 rpm for 40 s, baking at 170°C for 25 min, sputtering gold layer, and measuring thickness with ellipsometry. Reflectance and dispersion parameters are calculated and compared with theoretical models.
5：Data Analysis Methods:
Data is analyzed using equations for reflectance, phase, group delay, and GVD derived from the matrix method. Simulations are done for angular and wavelength interrogation cases.
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SF-10 glass
Used as a substrate prism in the SPR sensor setup.
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Te?on AF
Buffer layer to create symmetric profile and assist in multimode excitation.
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Gold film
Metal layer for surface plasmon resonance.
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Metamaterial layer
Layer between metals to enable multimode operation and dispersion tailoring.
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Silver layer
Additional metal layer in the multilayer structure.
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SAM layer
Self-assembled monolayer used as an analyte binding layer.
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Sputtering system
Used for depositing thin gold films.
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Spin coater
Used for applying Te?on layer.
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Ellipsometer
Used for measuring thickness of deposited layers.
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