研究目的
To extend understanding of how ultrasound waves propagate in the skull by exploring their near-field using laser ultrasonics techniques on mouse and human skull samples.
研究成果
Laser ultrasonics effectively reveal plate-like behavior in skull bone, with differences between mouse and human samples due to size and structure. The method is flexible and relevant for non-invasive imaging and therapeutic applications, but more work is needed for in vivo use and better understanding of wave properties.
研究不足
The theoretical model does not include porosity, leading to discrepancies with experimental data at lower frequencies. The method is applied to ex vivo samples, and in vivo applications require further development. The human skull's thick and scattering middle layer complicates wave observation.
1：Experimental Design and Method Selection:
The study uses laser ultrasonics to excite broadband ultrasound waves via thermoelastic effect from laser absorption in a black burnish layer on the skull's inner surface. A multilayered flat plate model is used for numerical simulations.
2：Sample Selection and Data Sources:
Fresh ex vivo mouse and human skull samples are immersed in
3：9% saline solution. List of Experimental Equipment and Materials:
A spherically focused ultrasound transducer (30 MHz for mouse, 15 MHz for human), laser pulses (10 ns duration, 532 nm wavelength), plano-convex lens, needle hydrophone, black burnish.
4：Experimental Procedures and Operational Workflow:
First, a pulse-echo scan maps the skull surface. Then, laser pulses are focused to excite waves, and the near-field is scanned with a hydrophone along a 3D path.
5：Data Analysis Methods:
Power spectral density analysis is performed, comparing experimental data with theoretical models.
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