研究目的
To present a case of cutaneous melanoma where diagnosis was aided by confocal microscopy examination and to correlate the observed features with dermoscopic and histopathological findings.
研究成果
In vivo confocal microscopy (ICM) shows good correlation with dermoscopy and histopathology, providing cellular-level visualization that aids in the non-invasive diagnosis of cutaneous melanoma. It serves as a valuable adjunct to dermoscopy, improving diagnostic accuracy before histopathological confirmation. The findings support ICM's role in early detection of low-risk melanomas, with high sensitivity and specificity reported in literature. Future research should focus on larger studies to validate these correlations and integrate ICM into standard diagnostic protocols.
研究不足
The study is limited to a single case report, which may not be generalizable to all cases of cutaneous melanoma. The correlation is qualitative and relies on visual interpretation, potentially introducing subjectivity. Specific equipment models and quantitative parameters are not detailed, limiting reproducibility. Future studies could benefit from larger sample sizes and quantitative analysis to enhance reliability.
1：Experimental Design and Method Selection:
A case study design was used to correlate findings from in vivo confocal microscopy (ICM), dermoscopy, and histopathology for diagnosing cutaneous melanoma. The rationale was to demonstrate the utility of ICM as a non-invasive diagnostic tool bridging clinical evaluation and histopathology.
2：Sample Selection and Data Sources:
A single case of a 69-year-old female patient with a 9-month history of a patch on the arm, diagnosed as cutaneous melanoma. The sample was selected based on clinical presentation and diagnostic needs.
3：List of Experimental Equipment and Materials:
In vivo confocal microscopy equipment for imaging, dermoscopy device for surface examination, and histopathology tools for tissue analysis. Specific models and brands are not mentioned in the paper.
4：Experimental Procedures and Operational Workflow:
Clinical examination was performed to identify the lesion. Dermoscopy was used to observe surface features. ICM was conducted to visualize microscopic structures in the epidermis and dermis. Histopathological examination was performed on a biopsy sample to confirm the diagnosis. Features from all methods were correlated step by step.
5：Data Analysis Methods:
Qualitative analysis was used to correlate visual features observed in dermoscopy, ICM, and histopathology. No statistical techniques or software tools were mentioned; the analysis was descriptive and based on direct observation and literature comparison.
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